Peptide Database

Peptide NameSparamosin26-54

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC147H234N46O36S5

DescriptionStandard

        GLGPNPCRKKCYKRDFLGRCRLNFTCMFG
    

Molecular Weight3382.04 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.1972

GRAVY Index-0.53

Hydrophobic Moment 0.33

Boman Index-0.21

Instability Index20.76

Aliphatic Index 40.34

Aromaticity 0.1379

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1350.14

LogP -13.16

H-bond Donors 52.0

H-bond Acceptors 47.0

Rotatable Bonds 111.0

Heavy Atoms 234.0

Ring Count 6.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019751 VERIFIED: YES

Provenance & Taxonomy

OrganismScylla paramamosain [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antibiofilm Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCryptococcus neoformans CGMCC No. 2.1563

Activity6-12 μM

MethodMIC

PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34690992/

RECORD: Rec_0023381 VERIFIED: YES

Provenance & Taxonomy

OrganismScylla paramamosain [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antibiofilm Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus CGMCC No. 1.2465

Activity12-24 μM

MethodMIC

PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34690992/

RECORD: Rec_0062665 VERIFIED: YES

Provenance & Taxonomy

OrganismScylla paramamosain [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antibiofilm Antifungal Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas stutzeri CGMCC No. 1.1803

Activity6-12 μM

MethodMIC

PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34690992/

RECORD: Rec_0099381 VERIFIED: YES

Provenance & Taxonomy

OrganismScylla paramamosain [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antibiofilm Antifungal Anti-Gram-positive Anti-Gram-negative

TargetAspergillus niger CGMCC No. 3.316

Activity6-12 μM

MethodMIC

PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34690992/

RECORD: Rec_0125272 VERIFIED: YES

Provenance & Taxonomy

OrganismScylla paramamosain [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antibiofilm Antifungal Anti-Gram-positive Anti-Gram-negative

TargetBacillus cereus CGMCC No. 1.3760

Activity24-48 μM

MethodMIC

PaperChen YC, Yang Y, Zhang C, et al. A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans. Front Microbiol. 2021;12:746006. DOI:10.3389/fmicb.2021.746006. PMID:34690992. PMID34690992 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34690992/

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