Peptide Database

Peptide NameBeta-defensin 25

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length71 amino acids

Chemical FormulaC345H548N98O93S7

DescriptionStandard

        MAKWILLIVALLVLGHVPSGSTEFKRCWNGQGACRTYCTRQEKFIHLCPDASLCCLSYSLKASPHSRAGGV
    

Molecular Weight7781.10 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)4.70

Net Charge (pH 7.4) 4.24

Charge Density (pH 7.0) 0.0662

GRAVY Index0.20

Hydrophobic Moment 0.53

Boman Index0.12

Instability Index57.24

Aliphatic Index 90.70

Aromaticity 0.0845

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3027.18

LogP -28.73

H-bond Donors 114.0

H-bond Acceptors 108.0

Rotatable Bonds 251.0

Heavy Atoms 543.0

Ring Count 14.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426500 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q32ZG7/entry; https://bblserver.org.in/ampdb/