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MYP_159461
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Basic Information
Crambin (Plant defensin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
46 amino acids
C202H321N55O64S6
Standard
Sequence
TTCCPSIVARSNFNVCRLPGTPEALCATYTGCIIIPGATCPGDYAN
Physicochemical Analysis
4736.43 Da
5.73
-0.66
-0.94
-0.0143
0.35
0.55
0.20
31.89
74.35
0.0652
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1858.84
-23.56
69.0
70.0
139.0
327.0
8.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0045490 VERIFIED: YES
Provenance & Taxonomy
Crambe hispanica subsp. abyssinica [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 6895315 | PubMed PMID: 21505232 PMID6895315;21505232 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6895315/
RECORD: Rec_0052875 VERIFIED: YES
Provenance & Taxonomy
Crambe hispanica subsp. abyssinica [Plant]
plant thionin (TC 1.C.44) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-40; 4-32; 16-26
Bio-Activity Profile
Antimicrobial plant thionin (TC 1.C.44) family Host defense
PaperPDB 2FD9 structural record; X-ray; 1.60 A; chain A; residues 1-46
RECORD: Rec_0083524 VERIFIED: YES
Provenance & Taxonomy
Crambe abyssinica [Plant]
Thionin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
-
PaperPubMed PMID 6895315 | PubMed PMID 3338468 | PubMed PMID 8000000 PMID6895315;3338468;8000000;68953;15333846;88000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6895315/
RECORD: Rec_0090582 VERIFIED: NO
Provenance & Taxonomy
Crambe hispanica subsp. abyssinica [Plant]
Thionin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCrambin Evidence URLhttps://www.uniprot.org/uniprotkb/P01542/entry
RECORD: Rec_0167424 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 41.3%, E 8.7%, T 30.4%, C 19.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/