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MYP_159447
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Basic Information
MU92 (Hepta 1 dp)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Standard
14 amino acids
C124H154N40O15
Standard
Sequence
RWWRWWRRWWRWWR
Physicochemical Analysis
2444.81 Da
12.00
5.76
5.56
0.4114
-2.44
1.11
-0.62
213.86
0.00
0.5714
44000.00
44000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
939.34
2.07
41.0
21.0
67.0
179.0
16.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015549 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Binding inhibition
HSV-1 | NP-2/CD4/CCR5 cells
3.3 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperApolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity. | Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB. | FEBS J. 2007 Sep;274(17):4511-25. | DOI:10.1111/j.1742-4658.2007.05981.x | PMID:17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0090764 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of virus infection in NP-2/CD4/CCR5 cells
3.3 μM
IC50
PaperPubMed PMID: 17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0104757 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antiviral
Sporozoite toxicity assay using Plasmodium berghei sporozoites
PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0120508 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antiviral
Staphylococcus aureus
PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0129411 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antiviral
Anti-HSV1 activity was assessed by plaque reduction assay
PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
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