Peptide Database

Peptide NameCetuximab

Function Ontology

Anticancer

Enzyme modulation ▸ Enzyme inhibition ▸ EGFR inhibitor

Standard StatusStandard

Sequence Length243 amino acids

Chemical FormulaC1157H1784N304O358S8

DescriptionStandard

        QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSPKSCDKTHTCPPCPAPELLGGP
    

Molecular Weight25936.88 Da

Isoelectric Point (pI)8.91

Net Charge (pH 7.0)6.04

Net Charge (pH 7.4) 5.48

Charge Density (pH 7.0) 0.0248

GRAVY Index-0.23

Hydrophobic Moment 0.53

Boman Index0.09

Instability Index51.77

Aliphatic Index 70.12

Aromaticity 0.0988

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44265.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0043774 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Monoclonal antibody EGFR inhibitor

Half-Life114 h

PaperPubMed-linked source references: PMID:28222590; PMID:28069552; PMID:27033349; PMID:26254368; PMID:26119717; PMID:25512619; PMID:24990295; PMID:24175095; PMID:24105075 PMID28222590;28069552;27033349;26254368;26119717;25512619;24990295;24175095;24105075 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28222590/ PatentCA1340417