Peptide Database

Peptide NamePancrelipase amylase

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length511 amino acids

Chemical FormulaC2556H3830N708O742S23

DescriptionStandard

        MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQPFANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL
    

Molecular Weight57085.54 Da

Isoelectric Point (pI)6.52

Net Charge (pH 7.0)-1.79

Net Charge (pH 7.4) -2.77

Charge Density (pH 7.0) -0.0035

GRAVY Index-0.31

Hydrophobic Moment 0.68

Boman Index0.05

Instability Index24.84

Aliphatic Index 71.14

Aromaticity 0.1292

Extinction Coeff. Reduced 138310.00

Extinction Coeff. Oxidized 139060.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0191870 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyEnzyme

Tax ID9823

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideDisulfide-bonded therapeutic scaffold described in source text

Bio-Activity Profile

Function

Enzyme replacement

Half-LifePancrelipase acts locally in the GI tract and it is not absorbed in any significant amount thus, the elimination half-life is not relevant.22