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MYP_159311
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Basic Information
D-Apidaecin-1B [1Orn,10 R], D-Api88
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XNNRPVYIPRPRPPHPRL
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0141675 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Tetramethylguanidino
O = L-ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
2 μg/mL
MIC
Mouse serum: Half-life time (mouse serum )=345 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0145160 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
unspecified non-canonical residue at 1
Bio-Activity Profile
Anticancer Cytotoxic
Human cervical carcinoma HeLa
600 μg/mL
IC50
PMID27285299;22594381 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
RECORD: Rec_0148700 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli BL21 DE3
4 μg/mL
MIC
PMID27285299;22594381 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
RECORD: Rec_0154746 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
unspecified non-canonical residue at 1
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae 123132
32 μg/mL
MIC
PMID27285299;22594381 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
RECORD: Rec_0156891 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
None
The 'O' in sequence is Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rat cardiomyocytes(IC50>0.6g/L)
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
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