Peptide Database

Peptide NamePhospholipase A2; membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Bacteriolytic activity ▸ Bacteriolytic enzyme

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length146 amino acids

Chemical FormulaC715H1117N199O203S17

DescriptionStandard

        MKVLLLLAVVIMAFGSIQVQGSLLEFGQMILFKTGKRADVSYGFYGCHCGVGGRGSPKDATDWCCVTHDCCYNRLEKRGCGTKFLTYKFSYRGGQISCSTNQDSCRKQLCQCDKAAAECFARNKKSYSLKYQFYPNKFCKGKTPSC
    

Molecular Weight16293.83 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)12.53

Net Charge (pH 7.4) 11.96

Charge Density (pH 7.0) 0.0858

GRAVY Index-0.25

Hydrophobic Moment 0.48

Boman Index-0.03

Instability Index33.88

Aliphatic Index 59.45

Aromaticity 0.1233

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 18295.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6531.96

LogP -69.74

H-bond Donors 244.0

H-bond Acceptors 235.0

Rotatable Bonds 547.0

Heavy Atoms 1134.0

Ring Count 24.0

Amide Bonds 157.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417450 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyPhospholipase A2

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriolytic enzyme Anti-Gram-positive Hydrolase Non-hemolytic

TargetGram Positive Bacteria