Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length502 amino acids

Chemical FormulaC2483H3931N655O704S15

DescriptionStandard

        VPGFSPRPGGFGSSEDEDMARGPDNNMQRWASLMVLAALGTAVTATTNPGIVARITQKGLDYACQQGTAVLKKELEKIKIPDFSGSFKVKVIGKGQYNFYSMFIHEFQLPSSQIKLLPNVGLNLIIENAGIKISGKWKAKKNFIKASGNFDLSLEGISILSALKLGCNSTTSHPDIYCTSCSSHVDSAHIHISGSSLGWLIQLFHKKIESSLRNALSSKICDVVRSSVTSKLQPFFQTLPVTAKIDDVAGIDYSLLAPPTATADGLDGQLKGEFFRLGHRSPPPFAPPPLAFPADHDRMVYLGVSDYFFNTAGLVYQQAGALHLTLRDDMIPKESRFRLTTQFFGTLIPQVGKMFPNMTVQLLISVSSPPHLTVHPTGLDLSPALETQAFAVLPNSTLAPLFLLGVSTNISVKVGIKSRRLVGELKLDRLLLQLKHSDIGAFSVESLQNVMNFLLPTVVLPRINARLQQGFPLPLPAHIQLLNLLLQSHQDFLMFGADVDYS
    

Molecular Weight54703.71 Da

Isoelectric Point (pI)9.02

Net Charge (pH 7.0)7.93

Net Charge (pH 7.4) 6.85

Charge Density (pH 7.0) 0.0158

GRAVY Index0.08

Hydrophobic Moment 0.66

Boman Index0.14

Instability Index38.84

Aliphatic Index 100.04

Aromaticity 0.0817

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0399169 VERIFIED: NO

Provenance & Taxonomy

OrganismGalemys pyrenaicus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence