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MYP_159046
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Basic Information
Cryptdin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
35 amino acids
C169H289N61O44S8
Standard
Sequence
LRDLVCYCRARGCKGRERMNGTCRKGHLLYMLCCR
Physicochemical Analysis
4136.00 Da
9.61
6.79
6.44
0.1939
-0.40
0.43
-0.32
13.77
66.86
0.0571
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1745.12
-18.04
72.0
60.0
142.0
282.0
3.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002099 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]; Mammalia [Animal]
10090; 40674
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0095220 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperPatent US 2008/0269122 A1 Evidence URLhttps://patents.google.com/patent/US20080269122A1/en PatentUS 2008/0269122 A1
RECORD: Rec_0100721 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli. Also killed Staphylococcus aureus based on virtual colony count assays (9.8 ug/ml killed 99.9%). This method exposed bacteria to peptides for 2 h in 10 mM phospahtate buffer before incubating in media for 12 h (Wang et al., 2023). Updated 7/2021, 2/2023
PaperMouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.
RECORD: Rec_0112665 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
10090
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
6-34, 8-23, 13-33
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0250298 VERIFIED: NO
Provenance & Taxonomy
Mus sp. [Animal]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ7197
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