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MYP_159023
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Basic Information
Antidiabetic peptide
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Stimulation activity
Standard
3 amino acids
C23H35N7O4
Standard
Sequence
IRW
Physicochemical Analysis
473.57 Da
9.75
0.76
0.56
0.2534
-0.30
0.99
-0.11
197.60
130.00
0.3333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.21
0.40
8.0
5.0
13.0
34.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0170365 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
10 μM
IC50
PaperQSAR-aided in silico approach in evaluation of food proteins as precursors of ACE inhibitory peptides
RECORD: Rec_0282597 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
9031.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Stimulatory
PaperLiao W., Bhullar K. S., Chakrabarti S., Davidge S. T., Wu J.. Egg white-derived tripeptide IRW (Ile-Arg-Trp) is an activator of Angiotensin Converting Enzyme 2. J. Agric. Food Chem., 66, 11330-11336, 2018.
RECORD: Rec_0306622 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0329405 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory
PaperMajumder K., Chakrabarti S., Morton J. S., Panahi S., Kaufman S., Davidge S. T., Wu J.. Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats. PLoS ONE, 8, e82829, 2013.
RECORD: Rec_0354850 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Angiotensin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Enzyme Activator ACE inhibitory
Angiotensin-I converting enzyme
0.61 μM
IC50
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