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MYP_159023
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Basic Information
Antidiabetic peptide
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Stimulation activity
Standard
3 amino acids
C23H35N7O4
Standard
Sequence
IRW
Physicochemical Analysis
473.57 Da
9.75
0.76
0.56
0.2534
-0.30
0.99
-0.11
197.60
130.00
0.3333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.21
0.40
8.0
5.0
13.0
34.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017187 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic
Paperde Campos Zani S. C., Son M., Bhullar K. S., Chan C. B., Wu J.. IRW (Isoleucine-Arginine-Tryptophan) improves glucose tolerance in high fat diet fed C57BL/6 mice via activation of insulin signaling and AMPK pathways in skeletal muscle. Biomedicines, 10, 1235, 2022.
RECORD: Rec_0019900 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]; Gallus gallus [Animal]
9913; 9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
RECORD: Rec_0117404 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
0.61
IC50
PaperMajumder K., Wu J.. Purification and characterisation of angiotensin I converting enzyme (ACE) inhibitory peptides derived from enzymatic hydrolysate of ovotransferrin. Food Chem., 126, 1614-1619, 2011.
RECORD: Rec_0143628 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
ACE-inhibitory peptide
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Yes
30 mmHg
SBP decrease
PaperEgg-derived peptide IRW inhibits TNF-????-induced inflammatory response and oxidative stress in endothelial cells
RECORD: Rec_0166640 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperMajumder K., Chakrabarti S., Morton J. S., Panahi S., Kaufman S., Davidge S. T., Wu J.. Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats. PLoS ONE, 8, e82829, 2013.
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