Peptide Database

Peptide NameHLP(Hirulog-like peptide)

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Thrombin inhibition ▸ Thrombin inhibitory

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC150H223N39O54

DescriptionStandard

        FPESKATNATLDPRPGGGGNGDFEEIPEEYLQ
    

Molecular Weight3436.60 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-5.23

Net Charge (pH 7.4) -5.44

Charge Density (pH 7.0) -0.1633

GRAVY Index-1.06

Hydrophobic Moment 0.47

Boman Index-0.06

Instability Index69.10

Aliphatic Index 42.81

Aromaticity 0.0938

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1489.47

LogP -17.34

H-bond Donors 47.0

H-bond Acceptors 49.0

Rotatable Bonds 108.0

Heavy Atoms 243.0

Ring Count 7.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071475 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHirudin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsI125 labeling

Bio-Activity Profile

Function

Thrombin inhibitor

MethodRadioisotopic tracing method

Half-LifeRat plasma, in vivo; 513.6 s