Peptide Database

Peptide NameSLAY-screened peptide P3865

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H159N29O25S2

DescriptionStandard

        VIPPTRHHGCNPTPPWLMLT
    

Molecular Weight2267.67 Da

Isoelectric Point (pI)8.24

Net Charge (pH 7.0)0.90

Net Charge (pH 7.4) 0.57

Charge Density (pH 7.0) 0.0449

GRAVY Index-0.26

Hydrophobic Moment 0.26

Boman Index0.16

Instability Index35.05

Aliphatic Index 73.00

Aromaticity 0.0500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 811.10

LogP -5.81

H-bond Donors 27.0

H-bond Acceptors 30.0

Rotatable Bonds 60.0

Heavy Atoms 159.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065714 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/