Peptide Database

Peptide NameSLAY-screened peptide P5707

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H172N34O28

DescriptionStandard

        RIITYWSALKNHFRTGSYPR
    

Molecular Weight2466.80 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)3.84

Net Charge (pH 7.4) 3.59

Charge Density (pH 7.0) 0.1922

GRAVY Index-0.76

Hydrophobic Moment 0.54

Boman Index-0.16

Instability Index-6.96

Aliphatic Index 63.50

Aromaticity 0.2000

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1028.09

LogP -8.73

H-bond Donors 39.0

H-bond Acceptors 33.0

Rotatable Bonds 76.0

Heavy Atoms 176.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0035122 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/