Peptide Database

Peptide NameAct Beta-defensin 2 (18-40)[C12I,G14p,P15G,C-del]

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC112H186N40O27S2

DescriptionStandard

        RCPGRTRQIGTIFPGRIKCRSW
    

Molecular Weight2589.06 Da

Isoelectric Point (pI)11.83

Net Charge (pH 7.0)5.74

Net Charge (pH 7.4) 5.51

Charge Density (pH 7.0) 0.2609

GRAVY Index-0.73

Hydrophobic Moment 0.42

Boman Index-0.31

Instability Index48.06

Aliphatic Index 53.18

Aromaticity 0.0909

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1111.93

LogP -12.08

H-bond Donors 44.0

H-bond Acceptors 35.0

Rotatable Bonds 83.0

Heavy Atoms 181.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0304886 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetCandida albicans ATCC 18804

Activity20 μM

MethodMFC

RECORD: Rec_0422202 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Bio-Activity Profile

Function

Hemolytic

TargetHuman erythrocytes

Activity80; 20 %

MethodHemolysis at 3 μM

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