Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length157 amino acids

Chemical FormulaC786H1189N177O238S9

DescriptionStandard

        QGIVYPAGNCSGPPYVAAPFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITIAEETCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATEIPIISLEQDSFTVEIQGSMEVFAVLPDSTPQSLFTMNIAANTSIALNIFDQKLMGSLCLNR
    

Molecular Weight17214.48 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-10.25

Net Charge (pH 7.4) -10.53

Charge Density (pH 7.0) -0.0653

GRAVY Index0.33

Hydrophobic Moment 0.55

Boman Index0.27

Instability Index50.79

Aliphatic Index 88.28

Aromaticity 0.1338

Extinction Coeff. Reduced 13410.00

Extinction Coeff. Oxidized 13535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6540.39

LogP -59.27

H-bond Donors 222.0

H-bond Acceptors 237.0

Rotatable Bonds 542.0

Heavy Atoms 1210.0

Ring Count 32.0

Amide Bonds 170.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0272925 VERIFIED: NO

Provenance & Taxonomy

OrganismEudyptes chrysocome [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence

RECORD: Rec_0276852 VERIFIED: NO