Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length548 amino acids

Chemical FormulaC2729H4349N757O758S21

DescriptionStandard

        MVAAAQQNRVVAKQEVLGMPPVALHTTLTSSSLFGRDIKVVWAGRAQHCTALQEARMGMQSVAVACGALALCLALTTATNPGFVVRMTQAGLDYAQQQGMAILEKELAQLKLPDISGKSGKVRYELSRLHLRDFHLPHSRITPISNVGLQVSISNAFAELNGDWRVKFLFIRDHGSFNLKVENVYMKIVLRLGSDTTGKPTISTSDCSASISKVRVRFSGKLGWLYNLFHSVIESKLRKSLERKVCDNVAKSVQNELQKQIQTLPVTARIDDKIGIDYSLVAPPRATAQSLDADLKWKPRFWNLLQMLFARVSRVNSTPWPTAPPPPSHRCHWPSPPDHERMVYFGASSYFFNTAGIAYHKAGALVFEITEAMIPKKAGFSLDTSAFSAFIPQLEEMYPNMPMKFRLSTPTAPFLTIGPGGISFQPIVDAQAYAILPNSSLAPLFLLSLTGNVSAVINVRSSRIVGSLDVGRIRLSLKDSAVGHFQVELLQSLMNILTSRVVMPHLNARLDEGFPLPLLDRIQLSNILVRFHQNFLLLGADIRFQPRG
    

Molecular Weight60564.71 Da

Isoelectric Point (pI)9.80

Net Charge (pH 7.0)20.70

Net Charge (pH 7.4) 19.59

Charge Density (pH 7.0) 0.0378

GRAVY Index0.04

Hydrophobic Moment 0.68

Boman Index0.08

Instability Index35.82

Aliphatic Index 98.07

Aromaticity 0.0803

Extinction Coeff. Reduced 53400.00

Extinction Coeff. Oxidized 53775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0148174 VERIFIED: NO

Provenance & Taxonomy

OrganismChloebia gouldiae [Bacterium]

FamilyBPI

Tax ID44316

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence