Peptide Database

Peptide NameChromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1; Chromofungin; Chromostatin; Chromacin; Pancreastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length449 amino acids

Chemical FormulaC2136H3404N626O738S11

DescriptionStandard

        MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG
    

Molecular Weight50014.35 Da

Isoelectric Point (pI)4.71

Net Charge (pH 7.0)-38.79

Net Charge (pH 7.4) -39.56

Charge Density (pH 7.0) -0.0864

GRAVY Index-1.20

Hydrophobic Moment 0.80

Boman Index-0.26

Instability Index73.94

Aliphatic Index 56.37

Aromaticity 0.0356

Extinction Coeff. Reduced 38960.00

Extinction Coeff. Oxidized 39085.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0406402 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyChromogranin secretogranin protein

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetB. cereus (Gram-positive)

RECORD: Rec_0425157 VERIFIED: YES