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MYP_158694
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Basic Information
Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1; Chromofungin; Chromostatin; Chromacin; Pancreastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
449 amino acids
C2136H3404N626O738S11
Standard
Sequence
MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG
Physicochemical Analysis
50014.35 Da
4.71
-38.79
-39.56
-0.0864
-1.20
0.80
-0.26
73.94
56.37
0.0356
38960.00
39085.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0288560 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
E. cloacae (Gram-negative)
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0314032 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
A. brassicicola
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0388665 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Listeria monocytogenes (Gram-positive)
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0389885 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli (Gram-negative)
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0389991 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
C. neoformans
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
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