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MYP_158694
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Basic Information
Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1; Chromofungin; Chromostatin; Chromacin; Pancreastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
449 amino acids
C2136H3404N626O738S11
Standard
Sequence
MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG
Physicochemical Analysis
50014.35 Da
4.71
-38.79
-39.56
-0.0864
-1.20
0.80
-0.26
73.94
56.37
0.0356
38960.00
39085.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005145 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
S. typhimurium
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0052284 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
F. culmorum
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0062039 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
A. benhamiae
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0072268 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Candida albicans
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
RECORD: Rec_0074110 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Chromogranin secretogranin protein
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
S. pyogenes (Gram-positive)
PMID1779968;3755681;3018587;3474638;9074643;12795588;1986917;2387861;8243650;1996343;1710890;2756155;8240272;8910482;10781584;7535395;7646465;9294131;9786174;10753865;10527498;15723172;21436258;9809795;11451958;14759560 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1779968/
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