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MYP_158690
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Basic Information
Pcr-R416A
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
23 amino acids
C114H184N32O35S
Standard
Sequence
CFLNITNSHVSILQEAPPLENRV
Physicochemical Analysis
2594.94 Da
5.40
-1.16
-1.43
-0.0503
0.07
0.45
0.11
69.80
114.35
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1084.17
-10.97
36.0
36.0
82.0
182.0
4.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0086561 VERIFIED: YES
Provenance & Taxonomy
Human T-lymphotropic virus 1 [Virus]
Virus-derived peptide
11908;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Sequence-variant derivative
Bio-Activity Profile
Antiviral Entry inhibitor
Human T-cell leukaemia virus 1 (Virus entry); 293T
1.55 μM
Luciferase assay
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0264792 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 17.4%, E 0.0%, T 43.5%, C 39.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0273578 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0314971 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HTLV Fusion inhibition
HTLV | T cell; 293T cells
1.55±0.08 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 Mar 6;284(10):6575-84. | DOI:10.1074/jbc.M806725200 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0406992 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human T cell leukemia virus type 1(HTLV-1):inhibition of mambrane fusion in 293T cells
1.55±0.08 μM
IC50
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/