Peptide Database

Peptide NamePhospholipase A2; membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Bacteriolytic activity ▸ Bacteriolytic enzyme

Enzyme / Catalytic activity ▸ Hydrolase

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length144 amino acids

Chemical FormulaC711H1128N202O204S18

DescriptionStandard

        MKTLLLLAVIMAIGLLQVHGDLLNFRKMIKLTTGKEPATRYSFYGCYCGMSGRGTPKDATDWCCRAHDCCYKNLESRGCRTKFLKYNVTYQEDQIVCEDADDCKSQVCQCDKIAANCFAANLKTYNKKLRFYNKFRCRGAAPAC
    

Molecular Weight16346.96 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)9.54

Net Charge (pH 7.4) 8.97

Charge Density (pH 7.0) 0.0662

GRAVY Index-0.30

Hydrophobic Moment 0.54

Boman Index-0.08

Instability Index29.50

Aliphatic Index 67.85

Aromaticity 0.1042

Extinction Coeff. Reduced 17420.00

Extinction Coeff. Oxidized 18295.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6619.59

LogP -66.22

H-bond Donors 246.0

H-bond Acceptors 234.0

Rotatable Bonds 549.0

Heavy Atoms 1135.0

Ring Count 21.0

Amide Bonds 155.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412574 VERIFIED: NO

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyPhospholipase A2

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriolytic enzyme Anti-Gram-positive Hydrolase Non-hemolytic

TargetGram Positive Bacteria