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MYP_158658
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Basic Information
Brevinin-1Yc (Frogs, amphibians, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C118H198N28O28S2
Standard
Sequence
FLPIIAGAAAKVVEKIFCAISKKC
Physicochemical Analysis
2521.14 Da
9.31
2.74
2.50
0.1141
1.16
0.63
0.35
7.00
126.25
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
885.44
-3.95
32.0
33.0
84.0
176.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0140838 VERIFIED: YES
Provenance & Taxonomy
Lithobates yavapaiensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
cancer cells HepG2
14 μM
LC50
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
RECORD: Rec_0155895 VERIFIED: YES
Provenance & Taxonomy
Lithobates yavapaiensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
13.0 μM
HC50
PaperJ.M. Conlon et al. / Toxicon 53 (2009) 699-705. Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
RECORD: Rec_0163808 VERIFIED: YES
Provenance & Taxonomy
Lithobates yavapaiensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Cytolytic
Candida albicans
6 μM
MIC
RECORD: Rec_0169421 VERIFIED: YES
Provenance & Taxonomy
Lithobates yavapaiensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human red blood cells
13 μM
LC50
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
RECORD: Rec_0212215 VERIFIED: YES
Provenance & Taxonomy
Lithobates yavapaiensis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
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