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MYP_158655
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Basic Information
[Met(O)75]apelin-15-(63-75)-peptide
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RRQRPRLSHKGPX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0191923 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 13 indicates oxidized methionine
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 11090199 PMID11090199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11090199/
RECORD: Rec_0280418 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
stereochemistry not specified [Other]
None
None
The 'X' at position 13 indicates oxidized methionine.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 | APJ cells
45 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperApelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. | Cayabyab M, Hinuma S, Farzan M, Choe H, Fukusumi S, Kitada C, Nishizawa N, Hosoya M, Nishimura O, Messele T, Pollakis G, Goudsmit J, Fujino M, Sodroski J. | J Virol. 2000 Dec;74(24):11972-6. | DOI:10.1128/jvi.74.24.11972-11976.2000 | PMID:11090199 PMID11090199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11090199/
RECORD: Rec_0410815 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 13 indicates oxidized methionine
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of HIV-1 infection in CD4 APJ cells
45 μM
IC50
PaperPubMed PMID: 11090199 PMID11090199 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11090199/