Peptide Database

Peptide NamesWWSP

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC67H114N20O16

DescriptionStandard

        PLIKLRLDRGQF
    

Molecular Weight1455.75 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.96

Net Charge (pH 7.4) 1.90

Charge Density (pH 7.0) 0.1632

GRAVY Index-0.27

Hydrophobic Moment 0.20

Boman Index-0.16

Instability Index-8.57

Aliphatic Index 130.00

Aromaticity 0.0833

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 599.64

LogP -3.39

H-bond Donors 22.0

H-bond Acceptors 18.0

Rotatable Bonds 50.0

Heavy Atoms 103.0

Ring Count 2.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006099 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (4) and Ⓓ (8) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Cytotoxic

TargetHeLa cells

Activity2 μM

MethodCytotoxicity

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0020903 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (4) and Ⓓ (8) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity30 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0035276 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (4) and Ⓓ (8) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity>256 μg/mL

MethodMIC

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

RECORD: Rec_0058055 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa

Activity256 μg/mL

MethodMIC

RECORD: Rec_0107216 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlactam side-chain cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsⓀ (4) and Ⓓ (8) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity15 μg/mL

MethodHemolysis

PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/

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