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MYP_158422
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Basic Information
Root cyclotide 1 (Vhr1)
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
30 amino acids
C133H212N34O41S6
Standard
Sequence
GIPCAESCVWIPCTVTALLGCSCSNKVCYN
Physicochemical Analysis
3135.70 Da
5.96
-0.30
-0.59
-0.0100
0.78
0.27
0.30
38.63
87.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1176.31
-13.34
46.0
47.0
94.0
214.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002385 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial
PaperPubMed PMID 15295104 PMID15295104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15295104/
RECORD: Rec_0030950 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0048783 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial cyclotide family Host defense
PaperPDB 1VB8 structural record; NMR; chain A; residues 4-30
RECORD: Rec_0093990 VERIFIED: NO
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15295104 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15295104/
RECORD: Rec_0129849 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 40.0%, E 0.0%, T 23.3%, C 36.7% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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