Peptide Database

Peptide NameFMRFamide-18

Function Ontology

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC65H95N17O19

DescriptionStandard

        TPPQPSDNFIRF
    

Molecular Weight1418.55 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-0.60

Net Charge (pH 7.4) -0.79

Charge Density (pH 7.0) -0.0501

GRAVY Index-0.93

Hydrophobic Moment 0.54

Boman Index-0.10

Instability Index60.84

Aliphatic Index 32.50

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 582.89

LogP -5.97

H-bond Donors 18.0

H-bond Acceptors 19.0

Rotatable Bonds 39.0

Heavy Atoms 101.0

Ring Count 5.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067982 VERIFIED: YES

Provenance & Taxonomy

OrganismLucilia cuprina [Animal]

FamilyFMRFamide related peptide

Tax ID7375

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

RECORD: Rec_0155536 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyFMRFamide-like peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0255175 VERIFIED: YES

Provenance & Taxonomy

OrganismLucilia cuprina [Animal]

FamilyFMRFamide

Tax ID7375

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neuromodulator

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0415158 VERIFIED: NO

Provenance & Taxonomy

OrganismLucilia cuprina [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide