Peptide Database

Peptide NameFMRFamide flp-7

Function Ontology

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC55H92N18O16S2

DescriptionStandard

        SPMQRSSMVRF
    

Molecular Weight1325.56 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)1.46

Net Charge (pH 7.4) 1.25

Charge Density (pH 7.0) 0.1327

GRAVY Index-0.52

Hydrophobic Moment 0.13

Boman Index-0.25

Instability Index92.78

Aliphatic Index 26.36

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 573.11

LogP -7.07

H-bond Donors 21.0

H-bond Acceptors 20.0

Rotatable Bonds 43.0

Heavy Atoms 91.0

Ring Count 2.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0116253 VERIFIED: NO

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

Tax ID6239

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0188839 VERIFIED: YES

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

FamilyFMRFamide related peptide

Tax ID6239

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

RECORD: Rec_0229433 VERIFIED: YES

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

FamilyFLP-7

Tax ID6239

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation

Targetand activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss (PubMed:33078707)

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0362470 VERIFIED: YES

Provenance & Taxonomy

OrganismCaenorhabditis elegans [Animal]

FamilyFLP-7

Tax ID6239

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Neuromodulator Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour