Peptide Database

Peptide NameSLAY-screened peptide P4741

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC103H153N27O34S

DescriptionStandard

        TQYSLSSCKINGYNPWTTAPN
    

Molecular Weight2345.54 Da

Isoelectric Point (pI)7.85

Net Charge (pH 7.0)0.39

Net Charge (pH 7.4) 0.18

Charge Density (pH 7.0) 0.0183

GRAVY Index-0.80

Hydrophobic Moment 0.35

Boman Index0.00

Instability Index11.07

Aliphatic Index 41.90

Aromaticity 0.1429

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1003.75

LogP -13.46

H-bond Donors 35.0

H-bond Acceptors 36.0

Rotatable Bonds 69.0

Heavy Atoms 165.0

Ring Count 6.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0274560 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/