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MYP_158223
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Basic Information
Protegrin 1/Neutrophil peptide 1/PG-1 [C6,8,13,15T][R10p]
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
18 amino acids
C91H153N33O24
Standard
Sequence
RGGRLTYTRPRFTVTVGR
Physicochemical Analysis
2093.40 Da
12.00
4.76
4.55
0.2644
-0.80
0.50
-0.37
3.94
53.89
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
959.88
-11.57
38.0
29.0
66.0
148.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011757 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis BR151
50-100 μg/mL
MIC
PMID17176094 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17176094/
RECORD: Rec_0033529 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecium A634
12.5-25 μg/mL
MIC
PMID17176094 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17176094/
RECORD: Rec_0035552 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli JM109
6.3 μg/mL
MIC
PMID17176094 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17176094/
RECORD: Rec_0065554 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus 1206
50 μg/mL
MIC
PMID17176094 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17176094/
RECORD: Rec_0082501 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protegrin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
APD analysis reveals that this sequence is unique and shows only very low similarity (72.22%) to PG-1 R: 28%, T: 22%, G: 17%. Chemical modification: central proline is a D-amino acid
Bio-Activity Profile
Antimicrobial
vancomycin-resistant E. faecium A634
12.5-25 μg/mL
MIC
PaperDesign of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues.
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