Peptide Database

Peptide NameSLAY-screened peptide P315

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC125H160N30O32

DescriptionStandard

        PYNVYHSFKHYHIYDDNWVP
    

Molecular Weight2594.79 Da

Isoelectric Point (pI)6.28

Net Charge (pH 7.0)-0.78

Net Charge (pH 7.4) -1.00

Charge Density (pH 7.0) -0.0391

GRAVY Index-1.09

Hydrophobic Moment 0.37

Boman Index0.03

Instability Index66.53

Aliphatic Index 48.50

Aromaticity 0.3000

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 983.22

LogP -4.62

H-bond Donors 34.0

H-bond Acceptors 34.0

Rotatable Bonds 73.0

Heavy Atoms 187.0

Ring Count 12.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0133807 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/