Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length463 amino acids

Chemical FormulaC2275H3661N583O658S18

DescriptionStandard

        MSPCCWLALLALVSPTLATNPGVKLKLTEKAIEYGKQIGIATLQQKLKTIQIPDIAGTEKVSPIGKVKYSLTEMKIVNLGLPKSDLTLVPGTGISLSITNAFINLHGNWRVRYLHVIKDSGSFDLAVSGLTVTDSLSILSDETGRPTVRGVNCEAIVGSASVKFHGGASWLYNLFSSFIDKALRSAMQKQICPLVADAINDMNQHLKTLNVLAKVDNHAEIEYSMVTPPSISKSSIDLNLKGEFYNIGKHQEPPFSPTPFSLPPQINNMLYIGVSAFTANTAGFVYNNAGVLGLRITDDMVRVPLATSSQFISKRFPGLMVELLVQTVKEPTISFQPNNVTVQASCTMTAYAVQTNSTLTPLFILNMEGSVSARLFVAGVMLAGAITLNKFEITLGTSYVGPFQVQSLDNIFRIVLKDVVIPQINVRLEKGFPLPTIGKMELINTELQVLKGYMLIGTDVKFT
    

Molecular Weight50285.08 Da

Isoelectric Point (pI)8.89

Net Charge (pH 7.0)6.00

Net Charge (pH 7.4) 5.31

Charge Density (pH 7.0) 0.0130

GRAVY Index0.22

Hydrophobic Moment 0.74

Boman Index0.18

Instability Index33.30

Aliphatic Index 106.29

Aromaticity 0.0734

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0382009 VERIFIED: NO

Provenance & Taxonomy

OrganismEsox lucius [Animal]

FamilyBPI

Tax ID8010

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence