‹ ›
MYP_157983
← PREVIOUS NEXT → BACK
Basic Information
TP4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
25 amino acids
C135H226N50O27
Standard
Sequence
FIHHIIGGLFSAGKAIHRLIRRRRR
Physicochemical Analysis
2981.56 Da
12.00
7.02
6.66
0.2808
-0.13
0.97
-0.16
130.24
117.20
0.0800
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1265.41
-9.63
49.0
37.0
102.0
212.0
5.0
24.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0377388 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Oreochromis niloticus [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Wound healing
Staphylococcus aureus
5 μM
MIC
PaperFive Different Piscidins from Nile Tilapia, Oreochromis niloticus: Analysis of Their Expressions and Biological Functions
RECORD: Rec_0386818 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Mouse erythrocytes
25 μg/mL
Hemolysis
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0401687 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Piscidin
8128
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Wound healing
Mammalian 1.1 h; Yeast 3 min; E. coli 2 min
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4 PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0415223 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Oreochromis niloticus [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Wound healing
E. tarda
20 μM
MIC
PaperFive Different Piscidins from Nile Tilapia, Oreochromis niloticus: Analysis of Their Expressions and Biological Functions
RECORD: Rec_0416572 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio alginolyticus
0.03 μg/mL
MIC
PMID23226256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226256/
FIRST PREV 1 ... 6 7 8
Showing 5 records on this page · Page 8 of 8