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MYP_157983
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Basic Information
TP4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
25 amino acids
C135H226N50O27
Standard
Sequence
FIHHIIGGLFSAGKAIHRLIRRRRR
Physicochemical Analysis
2981.56 Da
12.00
7.02
6.66
0.2808
-0.13
0.97
-0.16
130.24
117.20
0.0800
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1265.41
-9.63
49.0
37.0
102.0
212.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0238795 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antibacterial Antifungal Anticancer Wound healing Anti-Gram-positive Anti-Gram-negative Antimicrobial
Candida albicans
128 μg/mL
MIC
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0248741 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus,Tilapia nilotica [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
5 μM
MIC
RECORD: Rec_0261440 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Fish erythrocytes
100 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/23226256/ PMID23226256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226256/
RECORD: Rec_0265698 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Piscidin
8128
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-MDV Replication inhibition
Foot-and-Mouth Disease virus(FMDV) | BHK-21 cells
1.5±0.1 μg/mL
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperGrouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro. | Huang HN, Pan CY, Chen JY. | Peptides. 2018 Aug;106:91-95. | DOI:10.1016/j.peptides.2018.07.003 | PMID:30012343 PMID30012343 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30012343/
RECORD: Rec_0274881 VERIFIED: YES
Provenance & Taxonomy
Oreochromis niloticus [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 19660
0.52 μg/mL
MIC
PMID23226256 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23226256/
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