Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length465 amino acids

Chemical FormulaC2300H3726N636O631S17

DescriptionStandard

        MARGLDNVLGGAALVVLATAATAVTATTIPGFVARISQKGLDYASQQGVAVLQKELKNITIPNFSGAFMVKRLGEGNCNFYGLVIRDVRLPSSQITLVPNEGLKVSISANVKISGEWKAEVSFIKLRNKFNLNVQGISISADLKLGSDPISGHVTIACSSCRSNIKNIHIRGSRNLGLLIYLFRKKIELSLHRTMNDKICKVVTNSVSSKLQPYFQTLPVTAKTNSVAGVDYRLGEFFSLAHRSPPPFAPPAITFPHHRNHMVYLGISDYFFNTAGRVFQEAGDLKLAIKDVMIPKKSKIRLTTTYFGNLIPQVARMYPDMKVQLLISMSSPPHLSMHPIGLTFNPVLEAQAFAVLPNSSLASLFVLNMSTNVIVEVNATSGRLVGELQLGRLTLALKHSGVGPFSVKVLKNVMNFILPTIVLPRVNERMQRGFPLPLPARVQLSNLMVQSHKVSRQRPFSPQLP
    

Molecular Weight50929.17 Da

Isoelectric Point (pI)10.29

Net Charge (pH 7.0)29.43

Net Charge (pH 7.4) 28.52

Charge Density (pH 7.0) 0.0633

GRAVY Index0.13

Hydrophobic Moment 0.76

Boman Index0.11

Instability Index37.64

Aliphatic Index 104.15

Aromaticity 0.0710

Extinction Coeff. Reduced 18910.00

Extinction Coeff. Oxidized 19160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0194466 VERIFIED: NO

Provenance & Taxonomy

OrganismTupaia chinensis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence