Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length617 amino acids

Chemical FormulaC3113H4844N788O904S24

DescriptionStandard

        MGLMPYKRGSREIPGSLHCVRTQPEGADYEPGKRDHAGSLILDFPASRTVSSKFLLFICYSSPNRLTVTNIFFHQNVSSSWVQGSSGEHIVSKAEGIEGTPQLWMLPRLEMRTKAVQVLWGCFFLWNLCSSSTQTIYPGIKARVTQRALDYGIQAGMEMIEQMIKEKNIPDLKGSESLEFLKVDYVNYNFSNIKINVFSFPNTSLAFVPGVGIKALTNHGTANISTNWDVKSPLFQDTGEADLFLSGVYFTGIIVLSQNDFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYIELNLKGVFYPLDNLTDPPFLPVPFALPERSDSMLYVGISEFFFKSASFAYFIAGTFNVTLSMKEISNHLVQNSQGLGNMLSRIAEIYILSQPFMVRVMATEPPVISLLPGNFTLDIPASIVILTQPENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESSRSNIEVLRFENILSSILHFGILPLANAKLQQGIPLPNPHKISFVNSDVEVFEGFLLISTDLKYETSLKQQPSFHGWEGLSLMSGQWRGKPAA
    

Molecular Weight68542.06 Da

Isoelectric Point (pI)5.48

Net Charge (pH 7.0)-12.44

Net Charge (pH 7.4) -13.50

Charge Density (pH 7.0) -0.0202

GRAVY Index0.09

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index40.52

Aliphatic Index 98.41

Aromaticity 0.1005

Extinction Coeff. Reduced 65320.00

Extinction Coeff. Oxidized 65695.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0306962 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris (Dog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria