Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length426 amino acids

Chemical FormulaC2145H3388N572O599S11

DescriptionStandard

        AHQQGITILEKELAQLKLPDISGDFRIRHVGKVHYGISSMDLRSFHLPHSRISLVPNVGLQVAISNAFAEVDGNWRVKIQKSRDRGSFDLKVENIYIKINLKLGSDTSGKPTIDTSDCSTRISKVRVHFSGKFGWLYNLFHDAVESRFRKILENKVCTNVVSSVHSELQPYLQTLPVTARIDAMAGIDYSLVAPPTATAQALDAYLKGEFFSLAHRSAVPFPPLPLAFPPDHDRMVYFAASSYFFNTAGFAYHAAGALVFEITDSMIPKDVEFHLTTSTFSAFVPQLEKMYPDMPMKLRLSTLSAPFLSIGPGGLSLKPVVDVQAYAILPNSTLAPLFLLTLVSNVSAVIDIKSSHIVGSLNVGRMKLSLKHSDVGTFQVRTLQSIMNILASSILLPRLNARLEQGFPLPLLDRIQLSNVLVRFHQ
    

Molecular Weight47126.03 Da

Isoelectric Point (pI)9.33

Net Charge (pH 7.0)9.11

Net Charge (pH 7.4) 8.05

Charge Density (pH 7.0) 0.0214

GRAVY Index0.11

Hydrophobic Moment 0.66

Boman Index0.12

Instability Index35.13

Aliphatic Index 102.98

Aromaticity 0.0892

Extinction Coeff. Reduced 27390.00

Extinction Coeff. Oxidized 27515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010115 VERIFIED: NO

Provenance & Taxonomy

OrganismPelecanus crispus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria