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MYP_157807
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Basic Information
Arenicin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C127H195N41O25S2
Standard
Sequence
RWCVYAYVRVRGVLVRYRRCW
Physicochemical Analysis
2760.30 Da
10.85
5.74
5.50
0.2732
-0.07
0.54
-0.22
63.76
92.38
0.2381
15470.00
15595.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1108.99
-5.20
47.0
33.0
84.0
195.0
7.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039172 VERIFIED: YES
Provenance & Taxonomy
Arenicola marina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-20, 3-20
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic
Cytotoxicity: human embryonic fibroblasts (HEF) and human red blood cells (hRBC)
IC50
PMID15527787;17935487 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15527787/
RECORD: Rec_0048827 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Arenicin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
25 μM
Hemolysis
PaperCho J, Lee DG. The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. Biochem Biophys Res Commun. 2011 Feb 18;405(3):422-427. doi:10.1016/j.bbrc.2011.01.046. PMID21241661 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21241661/
RECORD: Rec_0054609 VERIFIED: NO
Provenance & Taxonomy
Arenicola marina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli, Listeria monocytogenes and fungus, Candida albicans
RECORD: Rec_0077649 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
1 μM
MIC
PMID31234579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31234579/
RECORD: Rec_0109953 VERIFIED: YES
Provenance & Taxonomy
Arenicola marina [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-20
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Host defense
PaperPDB 2JSB structural record; NMR; chain A; residues 1-21
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