Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2208H3433N571O636S22

DescriptionStandard

        MFLSVTAVLMLFSCAHGENPAIQVILTNKGLQYGKHAGTDWIQKMLEHVTLPDISGKVNVGFWCSIHYTLTNTSIEKCDLPEPSADFYPDATGLKTSMSGLSVALSGQWMTHFGIIHDKGSFDMAILGVDVTSVVELGKDADGHLSVSSANCVAQVGDVDVRFHGGASWIFKRFVKHFKKRISKEIENRICPNVEELIASVEYHLQAMNVSFEVDPAMAMNLSLSTSPTIDVSSLNLGLKGEFFSEKTRADPPFEAQPFTMPEQQAFMLSVGLSEFTLNSASYVYYSYGVFQRFIDDSMIPPGFPLHLNTSLMGPYVPQLPKMFPGLLMDLHVYARDTPMFSFQPGAVKLGIQGAVKAFAIQPNGTQTPLFQLNITDALENIARKVVEMGLEILNKRLGRGLVLPRLKRAQLVNSVLKVQEGFIALFSDADVFLTDRGFNQQN
    

Molecular Weight48858.75 Da

Isoelectric Point (pI)5.84

Net Charge (pH 7.0)-7.45

Net Charge (pH 7.4) -8.45

Charge Density (pH 7.0) -0.0168

GRAVY Index0.06

Hydrophobic Moment 0.91

Boman Index0.14

Instability Index31.46

Aliphatic Index 91.08

Aromaticity 0.0971

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150697 VERIFIED: NO

Provenance & Taxonomy

OrganismScophthalmus maximus [Bacterium]

FamilyBPI

Tax ID52904

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence