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MYP_157440
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Basic Information
EeCentrocin 1 Chain A (1-12)[G1A, D8A, N12K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C72H117N25O14
Standard
Sequence
AWWRRTVAKVRK
Physicochemical Analysis
1556.86 Da
12.00
4.79
4.60
0.3995
-0.98
0.66
-0.47
49.83
65.00
0.1667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
672.97
-4.04
27.0
19.0
50.0
111.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0034443 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
A2058
100 μM
IC50
PaperPubMed PMID: 31802582 PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0049296 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
0 %
Hemolysis
PaperPubMed PMID: 31802582 PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0058280 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pleurocidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
25 μM
MIC
PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0145253 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MRC-5
100 μM
IC50
PaperPubMed PMID: 31802582 PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0161515 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 31802582 PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
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