Peptide Database

Peptide NameSLAY-screened peptide P2673

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC98H160N32O25S

DescriptionStandard

        CFRGHPLNVLGNLLIASHTR
    

Molecular Weight2218.58 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.92

Net Charge (pH 7.4) 1.61

Charge Density (pH 7.0) 0.0962

GRAVY Index0.23

Hydrophobic Moment 0.39

Boman Index0.11

Instability Index-4.20

Aliphatic Index 117.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 915.23

LogP -8.96

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 70.0

Heavy Atoms 156.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0355063 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/