Peptide Database

Peptide NameSLAY-screened peptide P977

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC88H136N24O32

DescriptionStandard

        TQHSLHEPGTDLASSTTFL
    

Molecular Weight2042.16 Da

Isoelectric Point (pI)5.14

Net Charge (pH 7.0)-2.42

Net Charge (pH 7.4) -2.72

Charge Density (pH 7.0) -0.1276

GRAVY Index-0.43

Hydrophobic Moment 0.40

Boman Index0.08

Instability Index27.81

Aliphatic Index 66.84

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 894.99

LogP -12.30

H-bond Donors 31.0

H-bond Acceptors 32.0

Rotatable Bonds 63.0

Heavy Atoms 144.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0090181 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/