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MYP_157220
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Basic Information
Brevinin-2Ta
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Wound healing/Regeneration ▸ Wound healing
Standard
33 amino acids
C144H257N41O45S2
Standard
Sequence
GILDTLKNLAKTAGKGILKSLVNTASCKLSGQC
Physicochemical Analysis
3346.96 Da
9.60
3.74
3.50
0.1132
0.21
0.66
0.09
3.83
112.42
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1412.57
-17.36
51.0
51.0
119.0
232.0
0.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0244372 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP01908
RECORD: Rec_0281837 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0312015 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl. esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
64 μg/mL
MIC
PMID29340060 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29340060/
RECORD: Rec_0330362 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal Anti-inflammatory Wound healing
Staphylococcus aureus
20 μM
MIC
PaperAssessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats
RECORD: Rec_0354255 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal Anti-inflammatory Wound healing
Candida albicans
20 μM
MIC
PaperAssessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats
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