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MYP_157220
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Basic Information
Brevinin-2Ta
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Wound healing/Regeneration ▸ Wound healing
Standard
33 amino acids
C144H257N41O45S2
Standard
Sequence
GILDTLKNLAKTAGKGILKSLVNTASCKLSGQC
Physicochemical Analysis
3346.96 Da
9.60
3.74
3.50
0.1132
0.21
0.66
0.09
3.83
112.42
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1412.57
-17.36
51.0
51.0
119.0
232.0
0.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019568 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl. esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
32 μg/mL
MIC
PMID29340060 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29340060/
RECORD: Rec_0027992 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 63.6%, E 0.0%, T 21.2%, C 15.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0176029 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal Anti-inflammatory Wound healing
Escherichia coli
10 μM
MIC
PaperAssessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats
RECORD: Rec_0177531 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl. esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Horse RBCs
512 μg/mL
Hemolysis
PMID29340060 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29340060/
RECORD: Rec_0242045 VERIFIED: NO
Provenance & Taxonomy
Rana temporaria [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/P82268/entry
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