Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length403 amino acids

Chemical FormulaC1980H3210N536O566S12

DescriptionStandard

        MAECRRILLWVLTCLGLVLAEEDRSPAVMARITTKGLEYGLQKGVALLQQELSQTRLPDVTGKVKIIRGLEVQYKFHRLSIHDFQLPKARITPLQRVGLLVSIFDAFAELRGLWRVDSFLARASGHLSVEIEGISVFVRPRLGVDSSGKLTAAISYCITQVSEIRMKISSRQSSLSVFLKDVTEDVKRALEEQVCEVVTKVVELKVHPHLQSLPVRAMIDKAIGVDFSLVGPPLTTLNSLDIGLKGEFFSSSGPAAAPASPPRLCFPAEQSRMVYLATSSHFLSQAAEVFYQAGRPKFEITSDMIPGDAPVQLNTASFQSFIPQLQKLYPDAPMKLWITPSSAPLVTVDGGSLRAAAALDIQALAILPDAQEAPLFLLQASSSVAVRLAVESGRLVPRVELGR
    

Molecular Weight43964.70 Da

Isoelectric Point (pI)8.75

Net Charge (pH 7.0)4.03

Net Charge (pH 7.4) 3.36

Charge Density (pH 7.0) 0.0100

GRAVY Index0.19

Hydrophobic Moment 0.76

Boman Index0.11

Instability Index48.72

Aliphatic Index 108.88

Aromaticity 0.0645

Extinction Coeff. Reduced 25440.00

Extinction Coeff. Oxidized 25690.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0369091 VERIFIED: NO

Provenance & Taxonomy

OrganismVaranus komodoensis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence