Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2389H3791N611O666S15

DescriptionStandard

        DKGEKMLKTWYSFLLCWLSLRLEANPGLKVRITQNGLDYGRRIGMELLKQAVLKETFPSWSGQESFSVVKVNYVISRLRINAVDFPKTSASFIPGTGISLSVAHASATISADWRMNAWLLKDQGGITLSISGLFIAVIFRVSKDSTGHLSMLLHNCQLSINSVKVKLNGGSSWIYSFLSGFLEEPIRTKLDKNLCLNIKYKIQMMDAQLRKHKVLNQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGYHTDPPFVPAPFALPNEGDSMLYLGVSSYFLKSASLAYYRAGALNITISKELATTFNLNTTLFKDFVPEIAPSYLTACPVLLKLMATSPPAVSLNADRCILQITGCVEVLAVLPNSTTQYIFAGNLTASTRANLTITKQKLIISLLLKRLQFSLLHSTLGFSEMSLVENFLSYALWSAVIPVINDKLGKGFPLLNLAHTTLTGPVIKTNQGHLVISTDVHYK
    

Molecular Weight52209.32 Da

Isoelectric Point (pI)9.41

Net Charge (pH 7.0)15.58

Net Charge (pH 7.4) 14.68

Charge Density (pH 7.0) 0.0329

GRAVY Index0.21

Hydrophobic Moment 0.69

Boman Index0.16

Instability Index30.39

Aliphatic Index 108.44

Aromaticity 0.0951

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 62715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0165274 VERIFIED: NO

Provenance & Taxonomy

OrganismPygoscelis adeliae [Animal]

FamilyBPI/LBP

Tax ID9238

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria