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MYP_157171
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Basic Information
Indolicidin Peptide Derivative With P-->a Substitution
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
ILAWKWAWWAWRX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032078 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
unspecified non-canonical residue at 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC 25923
4 μg/mL
MIC (broth microdilution)
PaperFriedrich C, Moyles D, Beveridge TJ, Hancock REW. Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria. Antimicrob Agents Chemother. 2000;44:2086-2092. DOI:10.1128/AAC.44.8.2086-2092.2000. PMID11294848;10898680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11294848/
RECORD: Rec_0432588 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
unspecified non-canonical residue at 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus SAP0017 (MRSA)
4 μg/mL
MIC (broth microdilution)
PaperFriedrich C, Moyles D, Beveridge TJ, Hancock REW. Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria. Antimicrob Agents Chemother. 2000;44:2086-2092. DOI:10.1128/AAC.44.8.2086-2092.2000. PMID10898680
RECORD: Rec_0432589 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
unspecified non-canonical residue at 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus haemolyticus clinical isolate
2 μg/mL
MIC (broth microdilution)
PaperFriedrich C, Moyles D, Beveridge TJ, Hancock REW. Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria. Antimicrob Agents Chemother. 2000;44:2086-2092. DOI:10.1128/AAC.44.8.2086-2092.2000. PMID10898680
RECORD: Rec_0432590 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
unspecified non-canonical residue at 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus haemolyticus vancomycin-resistant isolate
1 μg/mL
MIC (broth microdilution)
PaperFriedrich C, Moyles D, Beveridge TJ, Hancock REW. Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria. Antimicrob Agents Chemother. 2000;44:2086-2092. DOI:10.1128/AAC.44.8.2086-2092.2000. PMID10898680
RECORD: Rec_0432591 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
unspecified non-canonical residue at 13
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus epidermidis clinical isolate
2 μg/mL
MIC (broth microdilution)
PaperFriedrich C, Moyles D, Beveridge TJ, Hancock REW. Antibacterial Action of Structurally Diverse Cationic Peptides on Gram-Positive Bacteria. Antimicrob Agents Chemother. 2000;44:2086-2092. DOI:10.1128/AAC.44.8.2086-2092.2000. PMID10898680
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