Peptide Database

Peptide NamePolymyxin B

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC59H108N16O13

DescriptionStandard

        KTKKKFLKKT
    

Molecular Weight1249.59 Da

Isoelectric Point (pI)10.70

Net Charge (pH 7.0)5.75

Net Charge (pH 7.4) 5.54

Charge Density (pH 7.0) 0.5754

GRAVY Index-1.82

Hydrophobic Moment 0.51

Boman Index-0.69

Instability Index0.51

Aliphatic Index 39.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 521.80

LogP -3.41

H-bond Donors 19.0

H-bond Acceptors 19.0

Rotatable Bonds 49.0

Heavy Atoms 88.0

Ring Count 1.0

Amide Bonds 9.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0318957 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus aerosporus [Bacterium]

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermLipidation

Other ModsWarning: the sequence is a close mimic of the natural peptide antibiotic. In the natural form, there are multiple Dab (2,4-diaminobutanoic acid), which are represented here as lysines. The molecule is cyclic due to the formation of an amide bond between the amino group of Dab in position 4 and the carboxyl group of the C-terminus. Polymyxin B is very similar (90%) to colistin with a change of F6 to L6

Bio-Activity Profile

Function

Antimicrobial Antifungal