Peptide Database

Peptide NameC12b(FIV ectodomain 770-781)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC76H103N19O18

DescriptionStandard

        WEDWVRWIGNIP
    

Molecular Weight1570.75 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.1030

GRAVY Index-0.54

Hydrophobic Moment 0.73

Boman Index0.16

Instability Index93.02

Aliphatic Index 89.17

Aromaticity 0.2500

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 601.59

LogP -0.73

H-bond Donors 21.0

H-bond Acceptors 17.0

Rotatable Bonds 44.0

Heavy Atoms 113.0

Ring Count 7.0

Amide Bonds 12.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0388700 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetFIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells

Activity0.09 μg/mL

MethodIC50

RECORD: Rec_0405261 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-FIV Entry inhibition

TargetFIV-Pet (Feline immunodeficiency virus Pet) | MBM cells

Activity0.09 μg/mL

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 Mar;77(6):3724-33. | DOI:10.1128/jvi.77.6.3724-3733.2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/

FIRST PREV 1 2

Showing 2 records on this page Ã‚Â· Page 2 of 2